Best Medicine is a comedy and drama series on FOX that premiered in 2026, with 2 seasons and 18 episodes to date. The next episode, Season 2 Episode 6, airs on Nov 3, 2026.
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ProductionPropagate Content, FOX Entertainment Studios
Martin Best is a brilliant surgeon who abruptly leaves his illustrious career in Boston to become the general practitioner in a quaint East Coast fishing village where he spent summers as a child. Unfortunately, Martin's blunt and borderline rude bedside manner rubs the quirky, needy locals the wrong way, and he quickly alienates the town, even though he's all they’ve got.
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Cast
Josh Charles
Dr. Martin Best
Abigail Spencer
Louisa Glasson
Josh Segarra
Sheriff Mark Mylow
Cree
Elaine Denham
Annie Potts
Aunt Joan
Stephen Spinella
Greg Garrison
Jason Veasey
George Brady
Eliza Coupe
Eden Montgomery
Seasons & Episodes2 seasons · 20 episodes
0% complete
E1Be Careful What You Fish For
Sep 20, 202644m
While Martin continues to struggle with his blood phobia, a mermaid washes ashore in Port Wenn to the amazement of everyone in town. Meanwhile, Judith, a well-meaning townsperson (guest star Andrea Martin), creates havoc while on prescribed oxygen, Louisa continues to see Martin's girlfriend Eden for medical guidance and Greg and George's success from the seas urchin boom take its toll on the both of them.
E2Breakin' In Is Hard to Do
Sep 29, 202644m
When the Port Wenn pharmacy is robbed, including Louisa’s critical time-sensitive medicine, Martin deduces that the culprit desperately needs his help. Meanwhile, Greg and George clash with a rival food truck owner, Sarah tries to bond with Eden, and Martin is on the receiving end of a special brand of Port Wenn affection.
E3Crate Expectations
Oct 6, 202644m
The citizens of Port Wenn get competitive during their annual floating crate race; Martin tries to give important medical advice when three men have positive pregnancy tests; former record-holder Sarah coaches Peter in the art of crate racing.
E4No Place Like Om
Oct 13, 202643m
As Martin desperately tries to leave Port Wenn to meet Eden in Boston for the weekend, he must first investigate the extremely strange behavior of three patients who have all recently visited a meditation retreat. Also, Mark is affected by the high school's graduation and Sarah's first guest in her rented spare room is none other than ex-paramour Eddie McCroy.
E5Hare Today, Gone Tomorrow
Oct 20, 202644m
When the wife of a traveling magician duo dies at the Salty Breeze, Martin must help the husband who is unable to grasp that she is gone. Also, Eden finds a letter Martin wrote to Louisa thinking it was for her and Martin gets a new medical monitor who has an instant connection to Louisa.
E7
E7Love Is a BattlefieldUPCOMING
Nov 10, 2026
E6
E6Can't Stop the HealingUPCOMING
Nov 3, 202644m
Martin works to debunk the sudden miraculous cures for the people of Port Wenn when self-proclaimed homeopath Savannah returns to town; Martin becomes acutely aware of Louisa and Parker's new connection.
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About Best Medicine
Best Medicine is a comedy, drama series on FOX. The show first aired on Jan 4, 2026 and currently has 2 seasons and 18 episodes. Best Medicine is currently airing; the next episode airs on Nov 3, 2026. It has a rating of 7.1/10 based on 34 votes. The cast includes Josh Charles, Abigail Spencer, Josh Segarra, Cree, Annie Potts. Created by Liz Tuccillo.
Best Medicine FAQ
How many seasons does Best Medicine have?
Best Medicine has 2 seasons and 18 episodes.
Is Best Medicine renewed or canceled?
Best Medicine is currently airing; the next episode airs on Nov 3, 2026.
Where can I watch Best Medicine?
Best Medicine is available on FOX. You can stream it on Netflix, Hulu, Fubo, YouTube TV, FOX One.
When is the next episode of Best Medicine?
The next episode of Best Medicine (S2 E6) airs on Nov 3, 2026.
