Martin Best is a brilliant surgeon who abruptly leaves his illustrious career in Boston to become the general practitioner in a quaint East Coast fishing village where he spent summers as a child. Unfortunately, Martin's blunt and borderline rude bedside manner rubs the quirky, needy locals the wrong way, and he quickly alienates the town, even though he's all they’ve got.
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Cast
Josh Charles
Dr. Martin Best
Abigail Spencer
Louisa Glasson
Josh Segarra
Sheriff Mark Mylow
Cree Cicchino
Elaine Denham
Annie Potts
Aunt Joan
Seasons & Episodes2 seasons · 17 episodes
E1Be Careful What You Fish ForUPCOMING
Sep 20, 2026
While Martin continues to struggle with his blood phobia, a mermaid washes ashore in Port Wenn to the amazement of everyone in town. Meanwhile, Judith, a well-meaning townsperson (guest star Andrea Martin), creates havoc while on prescribed oxygen, Louisa continues to see Martin's girlfriend Eden for medical guidance and Greg and George's success from the seas urchin boom take its toll on the both of them.
E2Breakin' In Is Hard to DoUPCOMING
Sep 29, 2026
When the Port Wenn pharmacy is robbed, including Louisa’s critical time-sensitive medicine, Martin deduces that the culprit desperately needs his help. Meanwhile, Greg and George clash with a rival food truck owner, Sarah tries to bond with Eden, and Martin is on the receiving end of a special brand of Port Wenn affection.
E3Crate ExpectationsUPCOMING
Oct 4, 2026
E4
E4No Place Like OmUPCOMING
Oct 6, 2026
About Best Medicine
Best Medicine is a comedy, drama series on FOX. The show first aired on Jan 4, 2026 and currently has 2 seasons and 17 episodes. Best Medicine has been renewed and is returning for more episodes. The next episode airs on Sep 20, 2026. It has a rating of 7.2/10 based on 27 votes. The cast includes Josh Charles, Abigail Spencer, Josh Segarra, Cree Cicchino, Annie Potts. Created by Liz Tuccillo.
